AE02: Evaluation of novel biofilm disrupting agents

Supervisory Team

Dr Ayesha Sabah Rahman, School of Pharmacy and  Dr Hazel Gibson  & Professor David Hill, School of Biology, Chemistry and Forensic Science

Project Description

Anti-microbial resistance (AMR) is a global problem and poses a great threat on our ability to treat infectious diseases. Among the resistance mechanisms, biofilm formation presents a complex challenge due to their structural complexity where the bacteria are attached to biotic or abiotic surfaces in an exopolymeric matrix resistant to the action of antibiotics and host immune response. The aim of the proposed project will be to elucidate the molecular mechanism of biofilm disrupting agents and evaluate the synergistic action of these agents with model antibiotics against clinically important Gram positive and Gram negative organisms. 

The successful candidate will be trained in a range of advanced techniques used in this study and develop skills in microbiology, biochemistry, and molecular biology. Laboratory work and characterization will be undertaken within the University of Wolverhampton’s new Science Centre, the Rosalind Franklin building, which houses a broad range of state-of-the-art research facilities suitable for undertaking this multidisciplinary project.

Eligibility

We welcome applications at any time from self-funded students that are well qualified and highly motivated. Applicants should have a recognized Honours or Masters degree with a 2.1 or equivalent in microbiology, biochemistry or molecular biology (or a related field).

Applicants whose entry award was not delivered in English, or non-native speaker of English shall be required to demonstrate proficiency in English at least to the level of an IELTS score of 7.0 or its equivalent.

How to apply

Complete the Research Project Application Form (Word doc 679k) and email to RIHS@wlv.ac.uk.

See Guidance for the Completion of the Research Project Application Form (Word doc 23k) for details.

For more information

For an informal discussion please contact Dr Ayesha Rahman (A.Rahman5@wlv.ac.uk ) or Dr Hazel Gibson (H.Gibson@wlv.ac.uk )